Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma
CHI3L1 (YKL-40) drives glioblastoma progression and immunosuppressive neuroimmune signaling, but as a non-enzymatic secreted glycoprotein it has lacked a g