World Wires · Story 72458 · corroborated · 1 Quelle(n)

The MASLD-causing E167K variant of TM6SF2 is degraded by the ubiquitin ligase RNF5

The TM6SF2 E167K loss-of-function variant is one of the most penetrant genetic risk factors for metabolic dysfunction-associated steatotic liver disease (M

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• The MASLD-causing E167K variant of TM6SF2 is degraded by the ubiquitin ligase RNF5 bioRxiv (new preprints) · Stufe C · Clear Net · 2026-10-23 00:00 UTC

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