Sex- and age-dependent control of dopamine function by LRRK2, and rapid reversal of dopamine release deficits in the LRRK2-G2019S knock-in mouse model of Parkinson's Disease.
No disease-modifying therapy exists for Parkinson's disease (PD). At diagnosis (~65y), ~70% of nigrostriatal dopamine (DA) axons may have degenerated, so i