Two novel missense variants altering cytosolic phospholipase A2α structural dynamics partially affect platelet signaling pathways associated with bleeding among Glanzmann thrombasthenia patients from two unrelated south Indian families
Cytosolic phospholipase A2 (cPLA2), encoded by PLA2G4A plays a crucial role in platelet activation through thromboxane A2 biosynthesis. Defects in this pat