A Three-Axis Framework for Therapy Prioritization in MBD4-Deficient Tumors: De-confounded Synthetic Lethality Modeling, Replication-Stress Pharmacology, and PARP1 Trapping Decoupling
Background: Loss-of-function mutations in MBD4 (methyl-CpG-binding domain protein 4) cause a specialized base excision repair (BER) deficiency characterize