PARP1-mediated PARylation of SPRTN restrains its DNA-protein crosslink repair activity
SPRTN is a DNA-dependent metalloprotease that resolves DNA-protein crosslinks, but how its activity is restrained on chromatin remains unclear. Here we sho
SPRTN is a DNA-dependent metalloprotease that resolves DNA-protein crosslinks, but how its activity is restrained on chromatin remains unclear. Here we sho